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The primary effect of DMT is the experience of intense hallucinations that alter the individual’s perception of the world around them.

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The main effect of DMT is psychological, with intense visual and auditory hallucinations, euphoria and an altered sense of space, body and time. Many users describe profound, life-changing experiences such as visiting other worlds, talking with alien entities and complete shifts in the perception of identity and reality.

In comparison to other psychedelic drugs (LSD, ketamine, magic mushrooms), recreational users of DMT consider it to have the lowest side effect profile.

Possible side effects of DMT may include:

  • Increased heart rate
  • Increased blood pressure
  • Chest pain or tightness
  • Agitation
  • Dilated pupils
  • Rapid rhythmic movements of the eye
  • Dizziness

When taken orally, DMT can cause nausea, vomiting and diarrhea.

Depending on the individual user, the DMT experience can be either intensely exciting or overwhelmingly frightening. The experience can be so powerful that users may have difficulty processing and integrating the “trip” into their real life. Mental side effects may linger for many days or weeks after ingestion of the drug.

Health risks of DMT

Because DMT is structurally related to the neurotransmitter serotonin, a condition called serotonin syndrome is a potentially lethal health risk that can be associated with its use. Individuals taking antidepressants are at highest risk for this complication.

Serotonin syndrome occurs when the body accumulates an excessive amount of serotonin. The condition is often caused by taking a combination of different drugs. Too much serotonin in the body can lead to symptoms such as:

  • Agitation
  • Confusion
  • High blood pressure
  • Loss of muscle coordination
  • Headache

At higher doses, DMT can cause seizures, respiratory arrest and coma.

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DMT could have serious adverse consequences for users with pre-existing psychological problems or a mental illness such as schizophrenia.

Due to limited research data, DMT is not known to cause physical dependence or addiction, although frequent recreational users may develop psychological cravings for the drug. The National Institute on Drug Abuse (NIDA) suggest that, unlike other hallucinogens, DMT use does not seem to induce tolerance of the drug.